Cellular magnesium homeostasis

Calcium and Magnesium Homeostasis

Mysteries of magnesium homeostasis.

In this issue of Circulation Research, Romani and colleagues1 report that insulin stimulates uptake of ionized magnesium (Mg) into heart. This study is the latest in a series by Romani, Scarpa, and colleagues regarding hormoneregulated Mg fluxes in heart and liver (References 1 and 2 and references therein). Over the past several decades, we have begun to uncover the mysteries of how cytosolic ...

Magnesium homeostasis and aging.

Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorpt...

Telomere Homeostasis: Interplay with Magnesium

Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the bio...

Magnesium homeostasis and alcohol consumption.

Clinical and experimental evidence indicates alcohol consumption as one of the major causes of magnesium loss from several tissues. As a result of this loss, serum magnesium tends to decrease while urinary magnesium excretion increases 2-3 fold. Experimental data confirm that chronic consumption of 6% ethanol in the Lieber De-Carli diet for 3 weeks results in a marked decrease in total tissue m...